Therapeutic microRNAs in polycystic kidney disease
نویسندگان
چکیده
منابع مشابه
MicroRNAs and Polycystic Kidney Disease.
Polycystic kidney disease (PKD), the most common genetic cause of chronic renal failure, is characterized by the presence of numerous fluid-filled cysts in renal parenchyma. Despite recent progress, no FDA-approved therapy is available to retard cyst growth. Here, we review current evidence implicating two groups of miRNAs - the miR-17~92 cluster and miR-200s - in the pathogenesis of PKD. We pr...
متن کاملPolycystic kidney disease and therapeutic approaches.
Polycystic kidney disease (PKD) is a common genetic disorder in which extensive epithelial-lined cysts develop in the kidneys. In previous studies, abnormalities of polycystin protein and its interacting proteins, as well as primary cilia, have been suggested to play critical roles in the development of renal cysts. However, although several therapeutic targets for PKD have been suggested, no e...
متن کامل[New therapeutic prospects in autosomal dominant polycystic kidney disease].
Correspondence: Roser Torra Enfermedades Renales Hereditarias Servicio de Nefrología Fundació Puigvert Barcelona [email protected] INTRODUCTION Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of ESRD in adults. There is currently no specific treatment for ADPKD, but great progress has been made in recent years in understanding of the cystogenesis process and the...
متن کاملLiver involvement in autosomal-dominant polycystic kidney disease: therapeutic dilemma.
Liver involvement is the most frequent extrarenal manifestation in autosomal-dominant polycystic kidney disease (ADPKD). Liver cysts are responsible for most hepatic complications, but other liver changes may occasionally be encountered, including congenital hepatic fibrosis and segmental dilation of the biliary tract. Both molecular and cellular changes implicated in liver cystogenesis have re...
متن کاملTherapeutic advances in the treatment of polycystic kidney disease.
The spectrum of polycystic kidney disease (PKD) comprises a family of inherited syndromes defined by renal cyst formation and growth, progressive renal function loss and variable extrarenal manifestations. The most common form, autosomal-dominant PKD is caused by mutations in one of two genes, PKD1 or PKD2. Recent developments in genomic and proteomic medicine have resulted in the discovery of ...
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ژورنال
عنوان ژورنال: Current Opinion in Nephrology and Hypertension
سال: 2017
ISSN: 1062-4821
DOI: 10.1097/mnh.0000000000000333